This Instant Pot Mississippi Pot Roast is a classic American comfort food made quicker and easier in the Instant Pot! Tender and juicy chuck roast beef is flavorful and loaded with salty pepperoncini peppers.

This Instant Pot Mississippi Pot Roast is a quick, throw-and-go simple recipe, just like our Instant Pot Country Style Ribs and Instant Pot BBQ Chicken Mac and Cheese! All you need are a few basic spices, chuck roast beef, and an instant pot. It’s one of those incredibly uncomplicated pot roast recipes that makes cooking dinner easy!

While classic Mississippi pot roast is made in the slow cooker, this instant pot version is just as tasty but ready in a fraction of the time. It’s pull-apart tender, incredibly moist, so flavorful, and deliciously served over creamy mashed potatoes or on sandwiches! Just like our smoked chuck roast, but without needing the smoker, it’s a great recipe with bonus built-in flavor!

What Is Mississippi Pot Roast?

Mississippi Roast is one of our favorite Instant Pot recipes! It’s made with a beef chuck roast that’s jazzed up with a ranch seasoning or a ranch-like herb blend, red wine, and pepperoncini peppers for an amazing flavor combo. Throw everything in the Instant Pot and let it work its magic. The result is this super tender roast, perfect for any occasion! Whether you need an easy recipe for busy weeknights or are tired of regular pot roast, this delicious dinner recipe is for you!

Mississippi Roast Ingredients

This Mississippi pot roast recipe is made up of just a few simple ingredients!

• Marinade – Head Country All-Purpose Marinade infuses so much flavor into the meat.
• Boneless Chuck Roast – We like to use chuck roast beef, but any tough meats from well-worked muscle groups work great.
• Salt – coating the beef in salt adds flavor and helps draw out the moisture for a more tender texture. We always use kosher salt.
• Cooking Oil – any cooking oil will work.
• Red Wine – adds moisture and a touch of warm sweetness to the beef. We’re also using it to deglaze the instant pot to prevent a burn notice from occurring.
• Onion Flakes, Garlic, and Chives – create a sweet and bright flavor base for the cooking liquid. Alternatively, some people love using dry Ranch dressing mix in the packet or dry onion soup mix. Just watch the salt in these.
• Low-sodium Beef Broth – infuses the meat with tons of moisture and flavor.
• Pepperoncini peppers – you can usually find pepperoncini peppers in jars in the condiment aisle next to the pickles and at your local market.

How to Make Mississippi Pot Roast in the Instant Pot

First, place the beef into a resealable bag, then pour the marinade over top. Seal, then marinate for 8 hours.

Remove the beef from the marinade and pat it dry. Season with salt. Set your instant pot to “SEAR” or hit the saute button, add the oil, then brown the beef for 3-5 minutes per side. Add the wine and use a wooden spoon to scrape the browned bits from the bottom.

Add the onion flakes, garlic, black pepper, parsley, chives, and broth. Place roast back in, then top with pepperoncini peppers. Set the instant pot to pressure cook and cook for 45 minutes.

Vent the steam naturally for 15 minutes, then manually quick release the rest, then let the beef roast rest for 5 minutes. After resting, use two forks to shred the beef, then serve!